Subtle changes in fractal motor activity regulation in cognitively healthy women may be a sign of preclinical Alzheimer’s disease, researchers report.
Depressed middle-aged carriers of the APOEe4 Alzheimer’s genetic variant are at risk of developing tau accumulations in brain areas associated with emotion and memory.
Adults over 80 who maintained a healthy lifestyle, including exercise and diet, had a lower risk of cognitive decline, even if they had genetic risk factors for dementia.
Retinal scans can help researchers detect Alzheimer’s disease and track its progression in those with the APOE4 genetic risk factor for the neurodegenerative disorder. The scans can detect blood vessel deterioration linked to the genetic biomarker.
Researchers identify five genetic loci linked to the progression of Parkinson’s disease.
Exercise helped to reduce cognitive decline two years later in Parkinson’s patients with the APOE e4 gene variant.
Researchers investigate the role the blood-brain barrier may play in age-related memory problems.
APOE4 affects lipid metabolism, but taking choline supplements may help protect carriers from developing Alzheimer’s disease and slow cognitive decline.
Both the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.
Altered pain perception could be a new biomarker to assess late-onset Alzheimer’s risk in cognitively healthy individuals with the AopE4 gene before symptoms occur.
People with the APOE4 genetic risk factor for Alzheimer’s disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, ra…
ApoE4, a gene associated with an increased risk of Alzheimer’s disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and a…
The Alzheimer’s risk gene ApoE4 hampers the process of endocytosis in astrocytes.
APOEe4, a gene associated with Alzheimer’s disease risk, doesn’t appear to directly affect memory performance or brain activity in older adults without cognitive impairment. However, the gene does seem to influence brain regions and systems that older …
Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline ov…
APOE4, a gene implicated as a risk factor for Alzheimer’s disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signa…
Carriers of one copy of the longevity associated klotho gene reduces Alzheimer’s risks by 30% for those with genetic risk factors for the neurodegenerative disease.